As part of the Deep Underground Neutrino Experiment (DUNE) near detector liquid argon prototyping program, four functionally-identical liquid argon time projection chamber (LArTPC) modules sharing a common cryostat will operate in Fermilab’s NuMI beamline in late 2022 in what is known as the ArgonCube 2x2 Demonstrator. Like any LArTPC, calibration of these modules is essential to pin down detector effects that affect our ability to make accurate physics measurements. Calibration studies are of particular interest in the case of these LArTPCs, as each module employs a novel pixelated charge readout comprised of nearly eighty thousand pixels. The first two modules built for the 2x2 project initially operated at the University of Bern in multiple runs spanning 2021 and 2022 and produced large data sets of cosmic ray events. We present an analysis of these events and highlight calibration studies of electron lifetime, electric field distortions, charge timing resolution, and reconstruction of delta rays and Michel electrons in pixelated LArTPCs.